InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FABP6

Summary

InnateDB Protein

IDBP-242525.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FABP6

Protein Name

fatty acid binding protein 6, ileal

Synonyms

I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3; ILLBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000377549

InnateDB Gene

IDBG-55997 (FABP6)

Protein Structure

UniProt Annotation

Function

Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis. {ECO:0000269PubMed:17909007}.

Subcellular Localization

Isoform 1: Cytoplasm.Isoform 2: Cytoplasm. Note=Localized close to nucleus on the apical side of both normal and neoplastic cells.

Disease Associations

Tissue Specificity

Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. {ECO:0000269PubMed:17909007}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008289	lipid binding

Biological Process

GO:0006629	lipid metabolic process
GO:0008206	bile acid metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0015721	bile acid and bile salt transport
GO:0044281	small molecule metabolic process