InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBM14

Summary

InnateDB Protein

IDBP-242531.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBM14

Protein Name

RNA binding motif protein 14

Synonyms

COAA; PSP2; SIP; SYTIP1; TMEM137;

Species

Homo sapiens

Ensembl Protein

ENSP00000377548

InnateDB Gene

IDBG-409430 (RBM14)

Protein Structure

UniProt Annotation

Function

Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1.

Subcellular Localization

Nucleus. Nucleus, nucleolus. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles.

Disease Associations

Tissue Specificity

Expressed in all tissues tested, including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	102 [view]
Protein-Protein	101 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0030674	protein binding, bridging
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006366	transcription from RNA polymerase II promoter
GO:0009725	response to hormone
GO:0016575	histone deacetylation
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0042921	glucocorticoid receptor signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter