InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLX1B

Summary

InnateDB Protein

IDBP-24270.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLX1B

Protein Name

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000328940

InnateDB Gene

IDBG-24268 (SLX1B)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. {ECO:0000255HAMAP-Rule:MF_03100, ECO:0000269PubMed:19595721, ECO:0000269PubMed:19596235, ECO:0000269PubMed:19596236}.

Subcellular Localization

Nucleus {ECO:0000255HAMAP-Rule:MF_03100, ECO:0000269PubMed:19596236}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008821	crossover junction endodeoxyribonuclease activity
GO:0017108	5'-flap endonuclease activity
GO:0046872	metal ion binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing