InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: REG3A

Summary

InnateDB Protein

IDBP-242724.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

REG3A

Protein Name

regenerating islet-derived 3 alpha

Synonyms

HIP; HIP/PAP; INGAP; PAP; PAP-H; PAP1; PBCGF; REG-III; REG3;

Species

Homo sapiens

Ensembl Protein

ENSP00000377456

InnateDB Gene

IDBG-58484 (REG3A)

Protein Structure

UniProt Annotation

Function

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. {ECO:0000269PubMed:16931762}.

Subcellular Localization

Secreted. Note=Found in the apical region of pancreatic acinar cells.

Disease Associations

Tissue Specificity

Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. {ECO:0000269PubMed:1469087, ECO:0000269PubMed:22727489}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030246	carbohydrate binding

Biological Process

GO:0006953	acute-phase response
GO:0007157	heterophilic cell-cell adhesion
GO:0007275	multicellular organismal development
GO:0008283	cell proliferation
GO:0010838	positive regulation of keratinocyte proliferation
GO:0045617	negative regulation of keratinocyte differentiation
GO:0090303	positive regulation of wound healing