Version 5.4
Homo sapiens Protein: TREX2
Summary
InnateDB Protein IDBP-242761.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TREX2
Protein Name three prime repair exonuclease 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000377442
InnateDB Gene IDBG-89424 (TREX2)
Protein Structure
UniProt Annotation
Function Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair. {ECO:0000269PubMed:11279105}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach and thymus. {ECO:0000269PubMed:11278605}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0008296 3'-5'-exodeoxyribonuclease activity
GO:0008853 exodeoxyribonuclease III activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR006055 Exonuclease
IPR012337 Ribonuclease H-like domain
IPR013520 Exonuclease, RNase T/DNA polymerase III
PFAM PF00929
PRINTS
PIRSF
SMART SM00479
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BQ50
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 11219
UniGene Hs.644635
RefSeq
HUGO HGNC:12270
OMIM 300540
CCDS CCDS35437
HPRD 02299
IMGT
EMBL AF151107 AF319570 AF319571 AF319572 AF319573 DQ145722
GenPept AAD48776 AAK07617 AAK07618 AAK07619 AAK07620 AAZ38719

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca