Version 5.4
Homo sapiens Gene: TREX2
Summary
InnateDB Gene IDBG-89424.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TREX2
Gene Name three prime repair exonuclease 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183479
Encoded Proteins
IDBP-89426
three prime repair exonuclease 2
IDBP-89428
three prime repair exonuclease 2
IDBP-89430
three prime repair exonuclease 2
IDBP-89432
three prime repair exonuclease 2
IDBP-89434
three prime repair exonuclease 2
IDBP-242761
three prime repair exonuclease 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]
This gene encodes a nuclear protein with 3\' to 5\' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:153444720-153470587
Strand Reverse strand
Band q28
Transcripts
ENST00000330912 ENSP00000333441
ENST00000338525 ENSP00000345218
ENST00000334497 ENSP00000334993
ENST00000370232 ENSP00000359252
ENST00000370231 ENSP00000359251
ENST00000393862 ENSP00000377442
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0008296 3'-5'-exodeoxyribonuclease activity
GO:0008853 exodeoxyribonuclease III activity
GO:0031996 thioesterase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0007067 mitotic nuclear division
GO:0051225 spindle assembly
GO:0051297 centrosome organization
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0070652 HAUS complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000031372
View Gene Order
Cross-References
SwissProt Q9BQ50
TrEMBL
UniProt Splice Variant
Entrez Gene 11219
UniGene Hs.644635
RefSeq NM_080701
HUGO HGNC:12270
OMIM 300370 300540
CCDS CCDS35437
HPRD 02299
IMGT
EMBL AF151107 AF319570 AF319571 AF319572 AF319573 DQ145722
GenPept AAD48776 AAK07617 AAK07618 AAK07619 AAK07620 AAZ38719
RNA Seq Atlas 11219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca