InnateDB Protein
|
IDBP-24281.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
YBX2
|
Protein Name
|
Y box binding protein 2
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000007699
|
InnateDB Gene
|
IDBG-24279 (YBX2)
|
Protein Structure
|
|
Function |
Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16479255}. Nucleus {ECO:0000269PubMed:16479255}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle. Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level). {ECO:0000269PubMed:10100484, ECO:0000269PubMed:16479255}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR002059
Cold-shock protein, DNA-binding
IPR011129
Cold shock protein
IPR012340
Nucleic acid-binding, OB-fold
|
PFAM |
PF00313
|
PRINTS |
PR00050
|
PIRSF |
|
SMART |
SM00357
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9Y2T7
|
PhosphoSite |
PhosphoSite-Q9Y2T7
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
51087
|
UniGene |
Hs.678212
|
RefSeq |
NP_057066
|
HUGO |
HGNC:17948
|
OMIM |
611447
|
CCDS |
CCDS11098
|
HPRD |
18311
|
IMGT |
|
EMBL |
AF096834
BC033800
BC047760
CH471108
|
GenPept |
AAD30662
AAH33800
AAH47760
EAW90223
EAW90224
|
|
|