InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSMC3IP

Summary

InnateDB Protein

IDBP-242892.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSMC3IP

Protein Name

PSMC3 interacting protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377384

InnateDB Gene

IDBG-51206 (PSMC3IP)

Protein Structure

UniProt Annotation

Function

Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. {ECO:0000269PubMed:10806355, ECO:0000269PubMed:16407260, ECO:0000269PubMed:21963259}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11739747}.

Disease Associations

Ovarian dysgenesis 3 (ODG3) [MIM:614324]: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. {ECO:0000269PubMed:21963259}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in testis and colon. {ECO:0000269PubMed:11739747, ECO:0000269PubMed:7490091}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity

Biological Process

GO:0006310	DNA recombination
GO:0007126	meiotic nuclear division
GO:0045892	negative regulation of transcription, DNA-templated
GO:2001141	regulation of RNA biosynthetic process