Version 5.4
Homo sapiens Gene: PSMC3IP
Summary
InnateDB Gene IDBG-51206.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSMC3IP
Gene Name PSMC3 interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131470
Encoded Proteins
IDBP-51208
PSMC3 interacting protein
IDBP-242892
PSMC3 interacting protein
IDBP-758212
IDBP-761410
IDBP-764797
IDBP-760283
IDBP-758276
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42572315-42577831
Strand Reverse strand
Band q21.2
Transcripts
ENST00000253789 ENSP00000253789
ENST00000393795 ENSP00000377384
ENST00000588544 ENSP00000465409
ENST00000590760 ENSP00000466381
ENST00000587268
ENST00000587209 ENSP00000468188
ENST00000589505
ENST00000590931 ENSP00000467952
ENST00000586337 ENSP00000466031
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0006310 DNA recombination
GO:0006355 regulation of transcription, DNA-templated
GO:0007126 meiotic nuclear division
GO:0007165 signal transduction
GO:0045892 negative regulation of transcription, DNA-templated
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019303
View Gene Order
ENSBTAG00000020907
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_27271
Meiotic recombination pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.383019
RefSeq NM_001256014 NM_001256015 NM_001256016 NM_013290 NM_016556
HUGO
OMIM
CCDS CCDS11431 CCDS45688 CCDS59289
HPRD 16362
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca