InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAP43

Summary

InnateDB Protein

IDBP-242930.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAP43

Protein Name

growth associated protein 43

Synonyms

B-50; PP46;

Species

Homo sapiens

Ensembl Protein

ENSP00000377372

InnateDB Gene

IDBG-50973 (GAP43)

Protein Structure

UniProt Annotation

Function

This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000269PubMed:14978216, ECO:0000269PubMed:21152083}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14978216}; Peripheral membrane protein {ECO:0000269PubMed:14978216}; Cytoplasmic side {ECO:0000269PubMed:14978216}. Cell projection, growth cone membrane {ECO:0000269PubMed:14978216}; Peripheral membrane protein {ECO:0000269PubMed:14978216}; Cytoplasmic side {ECO:0000269PubMed:14978216}. Cell junction, synapse {ECO:0000269PubMed:14978216}. Cell projection, filopodium membrane {ECO:0000269PubMed:14978216}; Peripheral membrane protein {ECO:0000269PubMed:14978216}. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0009611	response to wounding
GO:0010001	glial cell differentiation
GO:0016198	axon choice point recognition
GO:0040008	regulation of growth
GO:0042246	tissue regeneration
GO:0045165	cell fate commitment
GO:0051489	regulation of filopodium assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0031527	filopodium membrane
GO:0032584	growth cone membrane
GO:0045202	synapse
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001422 Neuromodulin (GAP-43)
IPR017454 Neuromodulin (GAP-43), C-terminal
IPR018947 Neuromodulin gap junction N-terminal

PFAM

PF00612
PF06614
PF10580

PRINTS

PR00215

PIRSF

SMART

SM00015

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt