InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CACNA2D1

Summary

InnateDB Protein

IDBP-24295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNA2D1

Protein Name

calcium channel, voltage-dependent, alpha 2/delta subunit 1

Synonyms

CACNA2; CACNL2A; CCHL2A; LINC01112; lncRNA-N3;

Species

Homo sapiens

Ensembl Protein

ENSP00000349320

InnateDB Gene

IDBG-24291 (CACNA2D1)

Protein Structure

UniProt Annotation

Function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta. {ECO:0000269PubMed:1309651, ECO:0000269PubMed:8107964}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006816	calcium ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0051924	regulation of calcium ion transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005891	voltage-gated calcium channel complex
GO:0016529	sarcoplasmic reticulum
GO:0030315	T-tubule
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR004010 Cache domain
IPR013608 VWA N-terminal
IPR013680 Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region

PFAM

PF00092
PF02743
PF08269
PF08399
PF08473

PRINTS

PIRSF

SMART

SM00327
SM01049

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P54289