Version 5.4
Homo sapiens Gene: CACNA2D1
Summary
InnateDB Gene IDBG-24291.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNA2D1
Gene Name calcium channel, voltage-dependent, alpha 2/delta subunit 1
Synonyms CACNA2; CACNL2A; CCHL2A; LINC01112; lncRNA-N3
Species Homo sapiens
Ensembl Gene ENSG00000153956
Encoded Proteins
IDBP-24293
calcium channel, voltage-dependent, alpha 2/delta subunit 1
IDBP-24295
calcium channel, voltage-dependent, alpha 2/delta subunit 1
IDBP-380492
calcium channel, voltage-dependent, alpha 2/delta subunit 1
IDBP-380495
calcium channel, voltage-dependent, alpha 2/delta subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:81946444-82443798
Strand Reverse strand
Band q21.11
Transcripts
ENST00000356253 ENSP00000348589
ENST00000356860 ENSP00000349320
ENST00000443883 ENSP00000409374
ENST00000423588 ENSP00000405395
ENST00000469297
ENST00000486539
ENST00000466806
ENST00000464354
ENST00000475237
ENST00000492734
ENST00000461275
ENST00000484706
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006816 calcium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0051924 regulation of calcium ion transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005891 voltage-gated calcium channel complex
GO:0016529 sarcoplasmic reticulum
GO:0030315 T-tubule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040118
View Gene Order
ENSBTAG00000020569
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.282151 Hs.592625 Hs.743228
RefSeq NM_000722 XM_005250572 XM_005250573 XM_005250574
HUGO
OMIM
CCDS CCDS5598
HPRD 00245
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca