InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DRD1

Summary

InnateDB Protein

IDBP-242985.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRD1

Protein Name

dopamine receptor D1

Synonyms

DADR; DRD1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000377353

InnateDB Gene

IDBG-58384 (DRD1)

Protein Structure

UniProt Annotation

Function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in caudate, nucleus accumbens and in the olfactory tubercle. {ECO:0000269PubMed:2144334}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001588	dopamine receptor activity, coupled via Gs
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0005515	protein binding
GO:0035240	dopamine binding

Biological Process

GO:0001659	temperature homeostasis
GO:0001661	conditioned taste aversion
GO:0001662	behavioral fear response
GO:0001963	synaptic transmission, dopaminergic
GO:0001975	response to amphetamine
GO:0006606	protein import into nucleus
GO:0006936	muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007416	synapse assembly
GO:0007612	learning
GO:0007613	memory
GO:0007617	mating behavior
GO:0007625	grooming behavior
GO:0007626	locomotory behavior
GO:0007628	adult walking behavior
GO:0007631	feeding behavior
GO:0008306	associative learning
GO:0008542	visual learning
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0014002	astrocyte development
GO:0015872	dopamine transport
GO:0019226	transmission of nerve impulse
GO:0019228	neuronal action potential
GO:0021542	dentate gyrus development
GO:0021756	striatum development
GO:0021766	hippocampus development
GO:0021853	cerebral cortex GABAergic interneuron migration
GO:0030335	positive regulation of cell migration
GO:0030432	peristalsis
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0035106	operant conditioning
GO:0042053	regulation of dopamine metabolic process
GO:0042220	response to cocaine
GO:0042311	vasodilation
GO:0042417	dopamine metabolic process
GO:0042493	response to drug
GO:0042711	maternal behavior
GO:0043268	positive regulation of potassium ion transport
GO:0046323	glucose import
GO:0046959	habituation
GO:0046960	sensitization
GO:0048148	behavioral response to cocaine
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051584	regulation of dopamine uptake involved in synaptic transmission
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0060134	prepulse inhibition
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway
GO:0060291	long-term synaptic potentiation
GO:0060292	long term synaptic depression
GO:0071870	cellular response to catecholamine stimulus

Cellular Component

GO:0005634	nucleus
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000929 Dopamine receptor family
IPR001413 Dopamine D1 receptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00242
PR00565
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21728