InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DRD1

Summary

InnateDB Gene

IDBG-58384.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRD1

Gene Name

dopamine receptor D1

Synonyms

DADR; DRD1A

Species

Homo sapiens

Ensembl Gene

ENSG00000184845

Encoded Proteins

IDBP-242985

dopamine receptor D1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:175440039-175444208

Strand

Reverse strand

Band

q35.2

Transcripts

ENST00000393752

ENSP00000377353

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001588	dopamine receptor activity, coupled via Gs
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0005515	protein binding
GO:0035240	dopamine binding

Biological Process

GO:0001659	temperature homeostasis
GO:0001661	conditioned taste aversion
GO:0001662	behavioral fear response
GO:0001963	synaptic transmission, dopaminergic
GO:0001975	response to amphetamine
GO:0006606	protein import into nucleus
GO:0006936	muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007416	synapse assembly
GO:0007612	learning
GO:0007613	memory
GO:0007617	mating behavior
GO:0007625	grooming behavior
GO:0007626	locomotory behavior
GO:0007628	adult walking behavior
GO:0007631	feeding behavior
GO:0008306	associative learning
GO:0008542	visual learning
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0014002	astrocyte development
GO:0015872	dopamine transport
GO:0019226	transmission of nerve impulse
GO:0019228	neuronal action potential
GO:0021542	dentate gyrus development
GO:0021756	striatum development
GO:0021766	hippocampus development
GO:0021853	cerebral cortex GABAergic interneuron migration
GO:0030335	positive regulation of cell migration
GO:0030432	peristalsis
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0035106	operant conditioning
GO:0042053	regulation of dopamine metabolic process
GO:0042220	response to cocaine
GO:0042311	vasodilation
GO:0042417	dopamine metabolic process
GO:0042493	response to drug
GO:0042711	maternal behavior
GO:0043268	positive regulation of potassium ion transport
GO:0046323	glucose import
GO:0046959	habituation
GO:0046960	sensitization
GO:0048148	behavioral response to cocaine
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051584	regulation of dopamine uptake involved in synaptic transmission
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0060134	prepulse inhibition
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway
GO:0060291	long-term synaptic potentiation
GO:0060292	long term synaptic depression
GO:0071870	cellular response to catecholamine stimulus

Cellular Component

GO:0005634	nucleus
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane