InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX60

Summary

InnateDB Protein

IDBP-242995.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX60

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377344

InnateDB Gene

IDBG-43861 (DDX60)

Protein Structure

UniProt Annotation

Function

Positively regulates DDX58/RIG-I- and IFIH1/MDA5- dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). {ECO:0000269PubMed:21478870, ECO:0000269PubMed:21791617}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21791617}.

Disease Associations

Tissue Specificity

Brain, lymph node, prostate, stomach, thyroid, tongue, trachea, uterus, skeletal muscle, spleen, kidney, liver and small intestine. {ECO:0000269PubMed:21791617}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0003727	single-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0008152	metabolic process
GO:0009615	response to virus
GO:0045087	innate immune response
GO:0051607	defense response to virus
GO:1900245	positive regulation of MDA-5 signaling pathway
GO:1900246	positive regulation of RIG-I signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04851
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IY21