InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CPLX2

Summary

InnateDB Protein

IDBP-243019.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPLX2

Protein Name

complexin 2

Synonyms

921-L; CPX-2; CPX2; Hfb1;

Species

Homo sapiens

Ensembl Protein

ENSP00000377346

InnateDB Gene

IDBG-58509 (CPLX2)

Protein Structure

UniProt Annotation

Function

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. {ECO:0000269PubMed:11483314, ECO:0000269PubMed:11576753, ECO:0000269PubMed:15906159, ECO:0000269PubMed:16162394, ECO:0000269PubMed:9853440}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019905	syntaxin binding

Biological Process

GO:0006836	neurotransmitter transport
GO:0006904	vesicle docking involved in exocytosis
GO:0007399	nervous system development
GO:0030154	cell differentiation
GO:0031915	positive regulation of synaptic plasticity
GO:0043303	mast cell degranulation