Version 5.4
Homo sapiens Gene: CPLX2
Summary
InnateDB Gene IDBG-58509.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPLX2
Gene Name complexin 2
Synonyms 921-L; CPX-2; CPX2; Hfb1
Species Homo sapiens
Ensembl Gene ENSG00000145920
Encoded Proteins
IDBP-58513
complexin 2
IDBP-243019
complexin 2
IDBP-474164
complexin 2
IDBP-484996
complexin 2
IDBP-477712
complexin 2
IDBP-477051
complexin 2
IDBP-480664
complexin 2
IDBP-479592
complexin 2
IDBP-475627
complexin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:175796310-175884020
Strand Forward strand
Band q35.2
Transcripts
ENST00000359546 ENSP00000352544
ENST00000393745 ENSP00000377346
ENST00000506642
ENST00000515502 ENSP00000423564
ENST00000509837 ENSP00000421106
ENST00000512824 ENSP00000425973
ENST00000514150 ENSP00000423612
ENST00000502265 ENSP00000424305
ENST00000515025 ENSP00000425284
ENST00000515094 ENSP00000421825
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0006836 neurotransmitter transport
GO:0006904 vesicle docking involved in exocytosis
GO:0007399 nervous system development
GO:0016079 synaptic vesicle exocytosis
GO:0030154 cell differentiation
GO:0031915 positive regulation of synaptic plasticity
GO:0043303 mast cell degranulation
Cellular Component
GO:0005829 cytosol
GO:0030425 dendrite
GO:0031201 SNARE complex
GO:0042629 mast cell granule
GO:0043025 neuronal cell body
GO:0045202 synapse
GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025867
View Gene Order
ENSBTAG00000013741
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.193235
RefSeq NM_001008220 NM_006650 XM_005265798 XM_005265799
HUGO
OMIM
CCDS CCDS4396
HPRD 09234
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca