InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RENBP

Summary

InnateDB Protein

IDBP-243089.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RENBP

Protein Name

renin binding protein

Synonyms

RBP; RNBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000377303

InnateDB Gene

IDBG-90655 (RENBP)

Protein Structure

UniProt Annotation

Function

Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. {ECO:0000269PubMed:9990133}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004857	enzyme inhibitor activity
GO:0004866	endopeptidase inhibitor activity
GO:0005524	ATP binding
GO:0017076	purine nucleotide binding
GO:0042803	protein homodimerization activity
GO:0050121	N-acylglucosamine 2-epimerase activity

Biological Process

GO:0006044	N-acetylglucosamine metabolic process
GO:0006051	N-acetylmannosamine metabolic process
GO:0008217	regulation of blood pressure
GO:0010951	negative regulation of endopeptidase activity
GO:0019262	N-acetylneuraminate catabolic process
GO:0043086	negative regulation of catalytic activity