Version 5.4
Homo sapiens Gene: RENBP
Summary
InnateDB Gene IDBG-90655.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RENBP
Gene Name renin binding protein
Synonyms RBP; RNBP
Species Homo sapiens
Ensembl Gene ENSG00000102032
Encoded Proteins
IDBP-90659
renin binding protein
IDBP-243089
renin binding protein
IDBP-383223
renin binding protein
IDBP-383227
renin binding protein
IDBP-383228
renin binding protein
IDBP-383231
renin binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:153935263-153944691
Strand Reverse strand
Band q28
Transcripts
ENST00000369997 ENSP00000359014
ENST00000393700 ENSP00000377303
ENST00000457282 ENSP00000405759
ENST00000423624 ENSP00000394220
ENST00000451114 ENSP00000409034
ENST00000442361 ENSP00000399278
ENST00000462086
ENST00000464227
ENST00000471056
ENST00000475904
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004857 enzyme inhibitor activity
GO:0004866 endopeptidase inhibitor activity
GO:0005524 ATP binding
GO:0017076 purine nucleotide binding
GO:0042803 protein homodimerization activity
GO:0050121 N-acylglucosamine 2-epimerase activity
Biological Process
GO:0006044 N-acetylglucosamine metabolic process
GO:0006051 N-acetylmannosamine metabolic process
GO:0008152 metabolic process
GO:0008217 regulation of blood pressure
GO:0010951 negative regulation of endopeptidase activity
GO:0019262 N-acetylneuraminate catabolic process
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031387
View Gene Order
ENSBTAG00000047827
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
INOH
INOH website
Aminosugars metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL A6NKZ2
UniProt Splice Variant
Entrez Gene 5973
UniGene Hs.158331 Hs.621685
RefSeq NM_002910
HUGO HGNC:9959
OMIM 312420
CCDS CCDS14738
HPRD 02423
IMGT
EMBL U52112
GenPept
RNA Seq Atlas 5973

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca