Version 5.4
Homo sapiens Protein: FBXO8
Summary
InnateDB Protein IDBP-243137.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO8
Protein Name F-box protein 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000377280
InnateDB Gene IDBG-44841 (FBXO8)
Protein Structure
UniProt Annotation
Function May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential). {ECO:0000305}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 8 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0030036 actin cytoskeleton organization
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR000904 Sec7 domain
IPR001810 F-box domain
PFAM PF01369
PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00222
SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRD0
PhosphoSite PhosphoSite-Q9NRD0
TrEMBL D6RIC0
UniProt Splice Variant
Entrez Gene 26269
UniGene Hs.76917
RefSeq NP_036312
HUGO HGNC:13587
OMIM 605649
CCDS CCDS3820
HPRD 07293
IMGT
EMBL AC097653 AF174596 AF201932 AF233224 AK314483 AY358721 BC014679 CH471056
GenPept AAF04517 AAF67154 AAF86868 AAH14679 AAQ89083 BAG37087 EAX04741 EAX04742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca