InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FBXO8

Summary

InnateDB Gene

IDBG-44841.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO8

Gene Name

F-box protein 8

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000164117

Encoded Proteins

IDBP-243137

F-box protein 8

IDBP-485395

F-box protein 8

IDBP-481397

F-box protein 8

IDBP-482305

F-box protein 8

IDBP-808885

F-box protein 8

IDBP-808887

F-box protein 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:174236658-174284264

Strand

Reverse strand

Band

q34.1

Transcripts

ENST00000393674	ENSP00000377280
ENST00000503293	ENSP00000422905
ENST00000515664	ENSP00000427313
ENST00000513696	ENSP00000427506
ENST00000620592	ENSP00000482582
ENST00000615392	ENSP00000484517

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	8 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0030036	actin cytoskeleton organization
GO:0032012	regulation of ARF protein signal transduction
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0030054	cell junction

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038206

View Gene Order

ENSBTAG00000006715

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

arf6_pathway

Arf6 signaling events

Cross-References

SwissProt

Q9NRD0

TrEMBL

D6RIC0

UniProt Splice Variant

Entrez Gene

26269

UniGene

Hs.699486 Hs.76917

RefSeq

NM_012180

HUGO

HGNC:13587

OMIM

605649

CCDS

CCDS3820

HPRD

07293

IMGT

EMBL

AC097653 AF174596 AF201932 AF233224 AK314483 AY358721 BC014679 CH471056

GenPept

AAF04517 AAF67154 AAF86868 AAH14679 AAQ89083 BAG37087 EAX04741 EAX04742

RNA Seq Atlas

26269