InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARAP1

Summary

InnateDB Protein

IDBP-243251.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARAP1

Protein Name

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377233

InnateDB Gene

IDBG-63550 (ARAP1)

Protein Structure

UniProt Annotation

Function

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.

Disease Associations

Tissue Specificity

Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea. {ECO:0000269PubMed:11804590}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0031702	type 1 angiotensin receptor binding

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008360	regulation of cell shape
GO:0030037	actin filament reorganization involved in cell cycle
GO:0032312	regulation of ARF GTPase activity
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051270	regulation of cellular component movement
GO:0051491	positive regulation of filopodium assembly
GO:0051497	negative regulation of stress fiber assembly

Cellular Component

GO:0005622	intracellular
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0032580	Golgi cisterna membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000198 Rho GTPase-activating protein domain
IPR001164 Arf GTPase activating protein
IPR001660 Sterile alpha motif domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00620
PF01412
PF00169
PF07647
PF00536

PRINTS

PR00405

PIRSF

SMART

SM00314
SM00324
SM00105
SM00454
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt