Version 5.4
Homo sapiens Gene: ARAP1
Summary
InnateDB Gene IDBG-63550.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARAP1
Gene Name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186635
Encoded Proteins
IDBP-63552
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
IDBP-63554
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
IDBP-243251
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
IDBP-243253
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
IDBP-380535
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
IDBP-380542
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
IDBP-380545
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
IDBP-380551
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
IDBP-380553
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
IDBP-592482
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
IDBP-591786
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:72685069-72793599
Strand Reverse strand
Band q13.4
Transcripts
ENST00000334211 ENSP00000335506
ENST00000359373 ENSP00000352332
ENST00000393609 ENSP00000377233
ENST00000393605 ENSP00000377230
ENST00000452383 ENSP00000399118
ENST00000427971 ENSP00000411452
ENST00000455638 ENSP00000390461
ENST00000426523 ENSP00000392264
ENST00000429686 ENSP00000403127
ENST00000495878
ENST00000465814
ENST00000544721
ENST00000542596 ENSP00000441741
ENST00000536885 ENSP00000442746
ENST00000541623
ENST00000542612
ENST00000544958
ENST00000543868
ENST00000536993
ENST00000546293
ENST00000542264
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
GO:0031702 type 1 angiotensin receptor binding
Biological Process
GO:0001921 positive regulation of receptor recycling
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008360 regulation of cell shape
GO:0030037 actin filament reorganization involved in cell cycle
GO:0032312 regulation of ARF GTPase activity
GO:0043089 positive regulation of Cdc42 GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051270 regulation of cellular component movement
GO:0051491 positive regulation of filopodium assembly
GO:0051497 negative regulation of stress fiber assembly
Cellular Component
GO:0005622 intracellular
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0032580 Golgi cisterna membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000032812
View Gene Order
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt Q96P48
TrEMBL F5GWN4 F8WBT0
UniProt Splice Variant
Entrez Gene 116985
UniGene Hs.503165
RefSeq NM_015242 NM_001040118 NM_001135190
HUGO HGNC:16925
OMIM 606646
CCDS CCDS8217 CCDS41687 CCDS44671
HPRD 09440
IMGT
EMBL AB018325 AB209473 AF411983 AJ621557 AP002381 AP003065 AY049732 AY553630 BC008315 BC021244 BC056401 BC140792
GenPept AAH08315 AAH56401 AAI40793 AAL04167 AAL12169 AAT36325 BAA34502 BAD92710 CAF21317
RNA Seq Atlas 116985

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca