InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COG4

Summary

InnateDB Protein

IDBP-243257.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COG4

Protein Name

component of oligomeric golgi complex 4

Synonyms

CDG2J; COD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000377236

InnateDB Gene

IDBG-40123 (COG4)

Protein Structure

UniProt Annotation

Function

Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. {ECO:0000269PubMed:19536132}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305PubMed:11703943}; Peripheral membrane protein {ECO:0000305PubMed:11703943}; Cytoplasmic side {ECO:0000305PubMed:11703943}.

Disease Associations

Congenital disorder of glycosylation 2J (CDG2J) [MIM:613489]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N- glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269PubMed:19494034}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0007030	Golgi organization
GO:0015031	protein transport
GO:0048213	Golgi vesicle prefusion complex stabilization