InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHLPP2

Summary

InnateDB Protein

IDBP-243445.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHLPP2

Protein Name

PH domain and leucine rich repeat protein phosphatase 2

Synonyms

PHLPPL;

Species

Homo sapiens

Ensembl Protein

ENSP00000377159

InnateDB Gene

IDBG-41059 (PHLPP2)

Protein Structure

UniProt Annotation

Function

Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. {ECO:0000269PubMed:17386267, ECO:0000269PubMed:18162466, ECO:0000269PubMed:19079341}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.

Disease Associations

Tissue Specificity

In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level). {ECO:0000269PubMed:19079341}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling