InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARFGEF1

Summary

InnateDB Protein

IDBP-24346.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARFGEF1

Protein Name

ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)

Synonyms

ARFGEP1; BIG1; P200;

Species

Homo sapiens

Ensembl Protein

ENSP00000262215

InnateDB Gene

IDBG-24344 (ARFGEF1)

Protein Structure

UniProt Annotation

Function

Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269PubMed:12571360, ECO:0000269PubMed:15644318, ECO:0000269PubMed:17227842, ECO:0000269PubMed:20360857, ECO:0000269PubMed:22084092}.

Subcellular Localization

Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network {ECO:0000250}. Nucleus. Nucleus, nucleolus. Nucleus matrix. Membrane. Note=Translocates from cytoplasm to membranes and nucleus upon cAMP treatment.

Disease Associations

Tissue Specificity

Expressed in placenta, lung, heart, brain, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0017022	myosin binding
GO:0034237	protein kinase A regulatory subunit binding

Biological Process

GO:0006887	exocytosis
GO:0007030	Golgi organization
GO:0010256	endomembrane system organization
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030837	negative regulation of actin filament polymerization
GO:0032012	regulation of ARF protein signal transduction
GO:0034259	negative regulation of Rho GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0090284	positive regulation of protein glycosylation in Golgi
GO:0090303	positive regulation of wound healing
GO:2000114	regulation of establishment of cell polarity

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0016363	nuclear matrix
GO:0030532	small nuclear ribonucleoprotein complex
GO:0048471	perinuclear region of cytoplasm