InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MDFIC

Summary

InnateDB Protein

IDBP-243520.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MDFIC

Protein Name

MyoD family inhibitor domain containing

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000377126

InnateDB Gene

IDBG-37093 (MDFIC)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin- beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. {ECO:0000269PubMed:10671520, ECO:0000269PubMed:12192039, ECO:0000269PubMed:12944466, ECO:0000269PubMed:16260749, ECO:0000269Ref.6}.

Subcellular Localization

Isoform 1: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm.Isoform 2: Cytoplasm {ECO:0000269PubMed:10671520, ECO:0000269PubMed:11139147, ECO:0000269PubMed:12944466, ECO:0000269PubMed:16260749}. Note=Weak expression in the nucleus.

Disease Associations

Tissue Specificity

Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine. {ECO:0000269PubMed:10671520}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0030332	cyclin binding
GO:0030957	Tat protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007257	activation of JUN kinase activity
GO:0016032	viral process
GO:0030111	regulation of Wnt signaling pathway
GO:0042308	negative regulation of protein import into nucleus
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050434	positive regulation of viral transcription