InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LINGO1

Summary

InnateDB Protein

IDBP-24366.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LINGO1

Protein Name

leucine rich repeat and Ig domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000347451

InnateDB Gene

IDBG-24364 (LINGO1)

Protein Structure

UniProt Annotation

Function

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients. {ECO:0000269PubMed:14686891, ECO:0000269PubMed:15895088, ECO:0000269PubMed:17726113}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0021954	central nervous system neuron development
GO:0031175	neuron projection development
GO:0043491	protein kinase B signaling
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0050770	regulation of axonogenesis
GO:0050771	negative regulation of axonogenesis

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set

PFAM

PF01462
PF00560
PF13504
PF13855
PF07679

PRINTS

PIRSF

SMART

SM00013
SM00369
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96FE5