InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDCD6IP

Summary

InnateDB Protein

IDBP-24375.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCD6IP

Protein Name

programmed cell death 6 interacting protein

Synonyms

AIP1; ALIX; DRIP4; HP95;

Species

Homo sapiens

Ensembl Protein

ENSP00000307387

InnateDB Gene

IDBG-24373 (PDCD6IP)

Protein Structure

UniProt Annotation

Function

Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation. {ECO:0000269PubMed:14505569, ECO:0000269PubMed:14505570, ECO:0000269PubMed:14739459, ECO:0000269PubMed:17428861, ECO:0000269PubMed:17556548, ECO:0000269PubMed:17853893}.

Subcellular Localization

Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 in the midbody during cytokinesis. Colocalized with CEP55 at centrosomes of non-dividing cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	112 [view]
Protein-Protein	111 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0015031	protein transport
GO:0016032	viral process
GO:0019058	viral life cycle
GO:0051301	cell division

Cellular Component

GO:0001772	immunological synapse
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0016020	membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome