InnateDB Protein
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IDBP-243792.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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B4GALNT2
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Protein Name
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beta-1,4-N-acetyl-galactosaminyl transferase 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377022
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InnateDB Gene
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IDBG-57461 (B4GALNT2)
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Protein Structure
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Function |
Involved in the synthesis of the Sd(a) antigen (Sia- alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain. {ECO:0000269PubMed:12678917, ECO:0000269PubMed:14688233}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Highly expressed in colon and to a lesser extent in kidney, stomach, ileum and rectum. {ECO:0000269PubMed:12678917}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0008376
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acetylgalactosaminyltransferase activity
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GO:0016758
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transferase activity, transferring hexosyl groups
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001173
Glycosyltransferase 2-like
IPR011143
Ganglioside GM2 synthase
IPR029044
Nucleotide-diphospho-sugar transferases
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PFAM |
PF00535
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PRINTS |
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PIRSF |
PIRSF000474
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NHY0
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PhosphoSite |
PhosphoSite-Q8NHY0
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TrEMBL |
Q8IVI2
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UniProt Splice Variant |
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Entrez Gene |
124872
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UniGene |
Hs.374679
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RefSeq |
NP_001152859
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HUGO |
HGNC:24136
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OMIM |
111730
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CCDS |
CCDS54139
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HPRD |
13558
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IMGT |
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EMBL |
AC069454
AF510036
AJ517770
AJ517771
AK302876
BC113675
BC113677
CH471109
S83275
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GenPept |
AAI13676
AAI13678
AAM34756
AAN86706
BAG64056
CAD57148
CAD57149
EAW94691
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