Version 5.4
Homo sapiens Gene: B4GALNT2
Summary
InnateDB Gene IDBG-57461.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B4GALNT2
Gene Name beta-1,4-N-acetyl-galactosaminyl transferase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167080
Encoded Proteins
IDBP-57463
beta-1,4-N-acetyl-galactosaminyl transferase 2
IDBP-243792
beta-1,4-N-acetyl-galactosaminyl transferase 2
IDBP-475099
beta-1,4-N-acetyl-galactosaminyl transferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary B4GALNT2 catalyzes the last step in the biosynthesis of the human Sd(a) antigen through the addition of an N-acetylgalactosamine residue via a beta-1,4 linkage to a subterminal galactose residue substituted with an alpha-2,3-linked sialic acid. B4GALNT2 also catalyzes the last step in the biosynthesis of the Cad antigen (Montiel et al., 2003 [PubMed 12678917]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:49132460-49169989
Strand Forward strand
Band q21.32
Transcripts
ENST00000300404 ENSP00000300404
ENST00000393354 ENSP00000377022
ENST00000504681 ENSP00000425510
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008376 acetylgalactosaminyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
Biological Process
GO:0006047 UDP-N-acetylglucosamine metabolic process
GO:0006486 protein glycosylation
GO:0019276 UDP-N-acetylgalactosamine metabolic process
GO:0022408 negative regulation of cell-cell adhesion
GO:0030259 lipid glycosylation
Cellular Component
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013418
View Gene Order
ENSBTAG00000009864
Not yet available
Cross-References
SwissProt Q8NHY0
TrEMBL Q8IVI2
UniProt Splice Variant
Entrez Gene 124872
UniGene Hs.374679
RefSeq NM_001159387 NM_001159388 NM_153446
HUGO HGNC:24136
OMIM 111730
CCDS CCDS54139 CCDS11544 CCDS54140
HPRD 13558
IMGT
EMBL AC069454 AF510036 AJ517770 AJ517771 AK302876 BC113675 BC113677 CH471109 S83275
GenPept AAI13676 AAI13678 AAM34756 AAN86706 BAG64056 CAD57148 CAD57149 EAW94691
RNA Seq Atlas 124872

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca