InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PICALM

Summary

InnateDB Protein

IDBP-243797.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PICALM

Protein Name

phosphatidylinositol binding clathrin assembly protein

Synonyms

CALM; CLTH; LAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000377015

InnateDB Gene

IDBG-66712 (PICALM)

Protein Structure

UniProt Annotation

Function

Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. {ECO:0000269PubMed:10436022}.

Subcellular Localization

Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Colocalized with clathrin in the Golgi area. Interaction with FAM64A may target PICALM to the nucleus in some cells.

Disease Associations

Note=A chromosomal aberration involving PICALM is found in diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with MLLT10.

Tissue Specificity

Expressed in all tissues examined. {ECO:0000269PubMed:8643484}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0005545	1-phosphatidylinositol binding
GO:0030276	clathrin binding
GO:0032050	clathrin heavy chain binding
GO:0035615	clathrin adaptor activity

Biological Process

GO:0006461	protein complex assembly
GO:0006898	receptor-mediated endocytosis
GO:0007409	axonogenesis
GO:0008283	cell proliferation
GO:0010629	negative regulation of gene expression
GO:0016188	synaptic vesicle maturation
GO:0016192	vesicle-mediated transport
GO:0016197	endosomal transport
GO:0030097	hemopoiesis
GO:0030100	regulation of endocytosis
GO:0031623	receptor internalization
GO:0032880	regulation of protein localization
GO:0035459	cargo loading into vesicle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0048268	clathrin coat assembly
GO:0048813	dendrite morphogenesis
GO:0055072	iron ion homeostasis
GO:0072583	clathrin-mediated endocytosis
GO:0097459	iron ion import into cell
GO:1901216	positive regulation of neuron death
GO:1902004	positive regulation of beta-amyloid formation
GO:1902959	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005905	coated pit
GO:0016020	membrane
GO:0030118	clathrin coat
GO:0030122	AP-2 adaptor complex
GO:0030132	clathrin coat of coated pit
GO:0031982	vesicle
GO:0042734	presynaptic membrane
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm
GO:0097418	neurofibrillary tangle