InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIMS1

Summary

InnateDB Protein

IDBP-243873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIMS1

Protein Name

LIM and senescent cell antigen-like domains 1

Synonyms

PINCH; PINCH-1; PINCH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000376987

InnateDB Gene

IDBG-65056 (LIMS1)

Protein Structure

UniProt Annotation

Function

Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.

Subcellular Localization

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Expressed in most tissues except in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0007569	cell aging
GO:0034329	cell junction assembly
GO:0045892	negative regulation of transcription, DNA-templated
GO:0071560	cellular response to transforming growth factor beta stimulus