Version 5.4
Homo sapiens Gene: LIMS1
Summary
InnateDB Gene IDBG-65056.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIMS1
Gene Name LIM and senescent cell antigen-like domains 1
Synonyms PINCH; PINCH-1; PINCH1
Species Homo sapiens
Ensembl Gene ENSG00000169756
Encoded Proteins
IDBP-65058
LIM and senescent cell antigen-like domains 1
IDBP-65060
LIM and senescent cell antigen-like domains 1
IDBP-243873
LIM and senescent cell antigen-like domains 1
IDBP-294953
LIM and senescent cell antigen-like domains 1
IDBP-294948
LIM and senescent cell antigen-like domains 1
IDBP-384312
LIM and senescent cell antigen-like domains 1
IDBP-384321
LIM and senescent cell antigen-like domains 1
IDBP-384322
LIM and senescent cell antigen-like domains 1
IDBP-384325
LIM and senescent cell antigen-like domains 1
IDBP-600563
LIM and senescent cell antigen-like domains 1
IDBP-594366
LIM and senescent cell antigen-like domains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:108534355-108687246
Strand Forward strand
Band q12.3
Transcripts
ENST00000332345 ENSP00000331775
ENST00000338045 ENSP00000337598
ENST00000393310 ENSP00000376987
ENST00000410093 ENSP00000386926
ENST00000409441 ENSP00000387264
ENST00000428064 ENSP00000390862
ENST00000449684
ENST00000422797 ENSP00000402322
ENST00000414829 ENSP00000399267
ENST00000434274 ENSP00000410751
ENST00000474038
ENST00000462817
ENST00000496653
ENST00000480744
ENST00000544547 ENSP00000437912
ENST00000542845 ENSP00000446121
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0007569 cell aging
GO:0034329 cell junction assembly
GO:0045892 negative regulation of transcription, DNA-templated
GO:0071560 cellular response to transforming growth factor beta stimulus
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019920
View Gene Order
ENSBTAG00000010971
Not yet available
Pathways
NETPATH
REACTOME
REACT_20580
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
KEGG
INOH
PID NCI
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL F8WB59
UniProt Splice Variant
Entrez Gene 3987
UniGene Hs.597715 Hs.647814 Hs.707108 Hs.714056
RefSeq NM_001193482 NM_001193483 NM_001193484 NM_001193485 NM_001193488 NM_004987
HUGO HGNC:6616
OMIM 602567
CCDS CCDS2078 CCDS54382 CCDS54383 CCDS54384 CCDS54385
HPRD 03978
IMGT
EMBL AC010095 AC012487
GenPept
RNA Seq Atlas 100288695 3987

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca