Homo sapiens Gene: LIMS1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-65056.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | LIMS1 | ||||||||||||||||||||||
Gene Name | LIM and senescent cell antigen-like domains 1 | ||||||||||||||||||||||
Synonyms | PINCH; PINCH-1; PINCH1 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000169756 | ||||||||||||||||||||||
Encoded Proteins |
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 1
LIM and senescent cell antigen-like domains 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 2:108534355-108687246 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q12.3 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
Cell-extracellular matrix interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
Integrin-linked kinase signaling
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | F8WB59 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 3987 | ||||||||||||||||||||||
UniGene | Hs.597715 Hs.647814 Hs.707108 Hs.714056 | ||||||||||||||||||||||
RefSeq | NM_001193482 NM_001193483 NM_001193484 NM_001193485 NM_001193488 NM_004987 | ||||||||||||||||||||||
HUGO | HGNC:6616 | ||||||||||||||||||||||
OMIM | 602567 | ||||||||||||||||||||||
CCDS | CCDS2078 CCDS54382 CCDS54383 CCDS54384 CCDS54385 | ||||||||||||||||||||||
HPRD | 03978 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC010095 AC012487 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 100288695 3987 | ||||||||||||||||||||||