InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERBB2IP

Summary

InnateDB Protein

IDBP-24411.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERBB2IP

Protein Name

erbb2 interacting protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000370330

InnateDB Gene

IDBG-24405 (ERBB2IP)

Protein Structure

UniProt Annotation

Function

Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. {ECO:0000269PubMed:10878805}.

Subcellular Localization

Cell junction, hemidesmosome {ECO:0000269PubMed:10878805, ECO:0000269PubMed:11375975}. Nucleus membrane {ECO:0000250}. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine. {ECO:0000269PubMed:10878805}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	82 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005176	ErbB-2 class receptor binding
GO:0005178	integrin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding

Biological Process

GO:0007049	cell cycle
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0016049	cell growth
GO:0045087	innate immune response (InnateDB)
GO:0045104	intermediate filament cytoskeleton organization
GO:0045175	basal protein localization
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity

Cellular Component

GO:0005604	basement membrane
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009925	basal plasma membrane
GO:0030056	hemidesmosome
GO:0031965	nuclear membrane