InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDGFD

Summary

InnateDB Protein

IDBP-244201.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDGFD

Protein Name

platelet derived growth factor D

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376865

InnateDB Gene

IDBG-69503 (PDGFD)

Protein Structure

UniProt Annotation

Function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000269PubMed:11331882}. Note=Released by platelets upon wounding.

Disease Associations

Tissue Specificity

Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines. {ECO:0000269PubMed:11331881, ECO:0000269PubMed:11331882, ECO:0000269PubMed:11342471, ECO:0000269PubMed:11980634, ECO:0000269PubMed:12427128, ECO:0000269PubMed:14514732, ECO:0000269PubMed:15988036}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005161	platelet-derived growth factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0007275	multicellular organismal development
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0051781	positive regulation of cell division
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005788	endoplasmic reticulum lumen
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome