InnateDB Protein
|
IDBP-244239.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
GRIA4
|
Protein Name
|
glutamate receptor, ionotrophic, AMPA 4
|
Synonyms
|
GluA4; GLUR4; GLUR4C; GLURD;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000376833
|
InnateDB Gene
|
IDBG-69728 (GRIA4)
|
Protein Structure
|
|
Function |
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269PubMed:21172611}.
|
Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
13
[view]
|
Protein-Protein |
13
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0004970
|
ionotropic glutamate receptor activity
|
GO:0004971
|
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
|
GO:0005234
|
extracellular-glutamate-gated ion channel activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001828
Extracellular ligand-binding receptor
IPR028082
Periplasmic binding protein-like I
|
PFAM |
PF01094
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P48058
|
PhosphoSite |
PhosphoSite-P48058
|
TrEMBL |
E9PJZ5
|
UniProt Splice Variant |
|
Entrez Gene |
2893
|
UniGene |
Hs.733043
|
RefSeq |
NP_001070712
|
HUGO |
HGNC:4574
|
OMIM |
138246
|
CCDS |
CCDS41707
|
HPRD |
00694
|
IMGT |
|
EMBL |
AP000641
AP000673
AP000813
AP001023
AP001561
BC045546
BC142654
BC150209
U16129
|
GenPept |
AAA95962
AAH45546
AAI42655
AAI50210
|
|
|