InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTPN

Summary

InnateDB Protein

IDBP-244338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTPN

Protein Name

myotrophin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376800

InnateDB Gene

IDBG-42874 (MTPN)

Protein Structure

UniProt Annotation

Function

Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. {ECO:0000250, ECO:0000269PubMed:10329199, ECO:0000269PubMed:16895918, ECO:0000269PubMed:20625546}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10329199}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006417	regulation of translation
GO:0006584	catecholamine metabolic process
GO:0010557	positive regulation of macromolecule biosynthetic process
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0016049	cell growth
GO:0016202	regulation of striated muscle tissue development
GO:0021707	cerebellar granule cell differentiation
GO:0030182	neuron differentiation
GO:0030307	positive regulation of cell growth
GO:0043403	skeletal muscle tissue regeneration
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051146	striated muscle cell differentiation
GO:0051247	positive regulation of protein metabolic process
GO:2000812	regulation of barbed-end actin filament capping

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008290	F-actin capping protein complex
GO:0030424	axon
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome