InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MTPN

Summary

InnateDB Gene

IDBG-42874.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTPN

Gene Name

myotrophin

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000105887

Encoded Proteins

IDBP-244338

myotrophin

IDBP-386603

myotrophin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

A bi-cistronic transcript encodes the products of both the myotrophin and leucine zipper protein 6 genes, which are located on chromosome 7. A cryptic ORF at the 3' end of the myotrophin transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008] The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:135926761-135977353

Strand

Reverse strand

Band

q33

Transcripts

ENST00000393085	ENSP00000376800
ENST00000435723	ENSP00000388321

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006417	regulation of translation
GO:0006584	catecholamine metabolic process
GO:0010557	positive regulation of macromolecule biosynthetic process
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0016049	cell growth
GO:0016202	regulation of striated muscle tissue development
GO:0021707	cerebellar granule cell differentiation
GO:0030182	neuron differentiation
GO:0030307	positive regulation of cell growth
GO:0043403	skeletal muscle tissue regeneration
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051146	striated muscle cell differentiation
GO:0051247	positive regulation of protein metabolic process
GO:2000812	regulation of barbed-end actin filament capping

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008290	F-actin capping protein complex
GO:0030424	axon
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029840

View Gene Order

ENSBTAG00000007806

Not yet available

Cross-References

SwissProt

P58546

TrEMBL

Q69YG1

UniProt Splice Variant

Entrez Gene

767558

UniGene

Hs.602015

RefSeq

NM_145808

HUGO

HGNC:15667

OMIM

606484 611050

CCDS

CCDS5842

HPRD

07574

IMGT

EMBL

AC015987 AF106075 AK056225 AL834231 BC028093 CH236950 CH471070

GenPept

AAH28093 AAP97226 BAG51651 CAD38909 EAL24056 EAW83859 EAW83860

RNA Seq Atlas

136319 767558