InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PCLO

Summary

InnateDB Protein

IDBP-24435.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCLO

Protein Name

piccolo (presynaptic cytomatrix protein)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000334319

InnateDB Gene

IDBG-24425 (PCLO)

Protein Structure

UniProt Annotation

Function

May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. {ECO:0000250UniProtKB:Q9QYX7}.

Subcellular Localization

Cell junction, synapse {ECO:0000250}. Note=Concentrated at the presynaptic side of synaptic junctions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0005544	calcium-dependent phospholipid binding
GO:0046872	metal ion binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0016079	synaptic vesicle exocytosis
GO:0017157	regulation of exocytosis
GO:0019933	cAMP-mediated signaling
GO:0030073	insulin secretion