Version 5.4
Homo sapiens Gene: PCLO
Summary
InnateDB Gene IDBG-24425.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCLO
Gene Name piccolo (presynaptic cytomatrix protein)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186472
Encoded Proteins
IDBP-24435
piccolo (presynaptic cytomatrix protein)
IDBP-380530
piccolo (presynaptic cytomatrix protein)
IDBP-380534
piccolo (presynaptic cytomatrix protein)
IDBP-380538
piccolo (presynaptic cytomatrix protein)
IDBP-380541
piccolo (presynaptic cytomatrix protein)
IDBP-812855
piccolo presynaptic cytomatrix protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:82754013-83162930
Strand Reverse strand
Band q21.11
Transcripts
ENST00000333891 ENSP00000334319
ENST00000432078
ENST00000423517 ENSP00000388393
ENST00000426442
ENST00000413807 ENSP00000404191
ENST00000456006 ENSP00000397928
ENST00000437081 ENSP00000393760
ENST00000461143
ENST00000618073 ENSP00000482390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005522 profilin binding
GO:0005544 calcium-dependent phospholipid binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0008152 metabolic process
GO:0016079 synaptic vesicle exocytosis
GO:0017157 regulation of exocytosis
GO:0019933 cAMP-mediated signaling
GO:0030073 insulin secretion
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005856 cytoskeleton
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0030054 cell junction
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061601
View Gene Order
ENSBTAG00000017350
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.12376
RefSeq NM_014510 NM_033026 XM_006715926
HUGO
OMIM
CCDS CCDS47630 CCDS47631
HPRD 16078
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca