InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM37

Summary

InnateDB Protein

IDBP-244363.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM37

Protein Name

tripartite motif containing 37

Synonyms

MUL; POB1; TEF3;

Species

Homo sapiens

Ensembl Protein

ENSP00000376785

InnateDB Gene

IDBG-61551 (TRIM37)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. {ECO:0000269PubMed:15885686, ECO:0000269PubMed:23769972}.

Subcellular Localization

Cytoplasm, perinuclear region. Peroxisome. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.

Disease Associations

Mulibrey nanism (MUL) [MIM:253250]: Autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common. {ECO:0000269PubMed:15108285, ECO:0000269PubMed:15885686, ECO:0000269PubMed:17100991}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10888877}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.

Experimentally validated
Total	53 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0046600	negative regulation of centriole replication
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051865	protein autoubiquitination
GO:0070842	aggresome assembly