InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRIM37

Summary

InnateDB Gene

IDBG-61551.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM37

Gene Name

tripartite motif containing 37

Synonyms

MUL; POB1; TEF3

Species

Homo sapiens

Ensembl Gene

ENSG00000108395

Encoded Proteins

IDBP-61553

tripartite motif containing 37

IDBP-244363

tripartite motif containing 37

IDBP-244365

tripartite motif containing 37

IDBP-760860

IDBP-757798

IDBP-763755

IDBP-759438

IDBP-758553

IDBP-761719

IDBP-757775

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23438823

TRIM37 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:58982638-59106921

Strand

Reverse strand

Band

q22

Transcripts

ENST00000262294	ENSP00000262294
ENST00000393066	ENSP00000376785
ENST00000393065	ENSP00000376784
ENST00000580973	ENSP00000464590
ENST00000583945	ENSP00000462778
ENST00000585287	ENSP00000464666
ENST00000581468	ENSP00000462863
ENST00000584889	ENSP00000464263
ENST00000583387
ENST00000580620
ENST00000577554	ENSP00000462340
ENST00000582852
ENST00000580122	ENSP00000464688

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.

Experimentally validated
Total	53 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0046600	negative regulation of centriole replication
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051865	protein autoubiquitination
GO:0070842	aggresome assembly

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0016235	aggresome
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000018548

View Gene Order

ENSBTAG00000021677

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.579079 Hs.605697

RefSeq

NM_001005207 NM_015294 XM_005257387

HUGO

OMIM

CCDS

CCDS32694 CCDS45746

HPRD

05463

IMGT

EMBL

GenPept

RNA Seq Atlas