InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DBH

Summary

InnateDB Protein

IDBP-244403.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DBH

Protein Name

dopamine beta-hydroxylase (dopamine beta-monooxygenase)

Synonyms

DBM;

Species

Homo sapiens

Ensembl Protein

ENSP00000376776

InnateDB Gene

IDBG-91512 (DBH)

Protein Structure

UniProt Annotation

Function

Conversion of dopamine to noradrenaline.

Subcellular Localization

Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen.Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Dopamine beta-hydroxylase deficiency (DBH deficiency) [MIM:223360]: Characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction. {ECO:0000269PubMed:11857564}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004497	monooxygenase activity
GO:0004500	dopamine beta-monooxygenase activity
GO:0005507	copper ion binding
GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0001816	cytokine production
GO:0001974	blood vessel remodeling
GO:0001975	response to amphetamine
GO:0002443	leukocyte mediated immunity
GO:0007268	synaptic transmission
GO:0007613	memory
GO:0007626	locomotory behavior
GO:0008306	associative learning
GO:0008542	visual learning
GO:0034641	cellular nitrogen compound metabolic process
GO:0042127	regulation of cell proliferation
GO:0042309	homoiothermy
GO:0042420	dopamine catabolic process
GO:0042421	norepinephrine biosynthetic process
GO:0042423	catecholamine biosynthetic process
GO:0042593	glucose homeostasis
GO:0042596	fear response
GO:0042711	maternal behavior
GO:0044281	small molecule metabolic process
GO:0045907	positive regulation of vasoconstriction
GO:0048149	behavioral response to ethanol
GO:0048265	response to pain
GO:0050900	leukocyte migration
GO:0055114	oxidation-reduction process
GO:2001236	regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030658	transport vesicle membrane
GO:0034466	chromaffin granule lumen
GO:0034774	secretory granule lumen
GO:0042584	chromaffin granule membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
IPR000945 Dopamine beta-hydroxylase-related
IPR005018 DOMON domain
IPR008977 PHM/PNGase F domain

PFAM

PF01082
PF03351

PRINTS

PR00767

PIRSF

SMART

SM00664

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt