InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: XRN1

Summary

InnateDB Protein

IDBP-244529.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XRN1

Protein Name

5'-3' exoribonuclease 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376707

InnateDB Gene

IDBG-59457 (XRN1)

Protein Structure

UniProt Annotation

Function

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250, ECO:0000269PubMed:18172165}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12515382, ECO:0000269PubMed:14580940, ECO:0000269PubMed:9802570}. Note=Discrete foci at the inner surface of the cell membrane.

Disease Associations

Tissue Specificity

Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines. {ECO:0000269PubMed:12426100}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.

Experimentally validated
Total	74 [view]
Protein-Protein	74 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0008409	5'-3' exonuclease activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000956	nuclear-transcribed mRNA catabolic process
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0016075	rRNA catabolic process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0071028	nuclear mRNA surveillance
GO:0071044	histone mRNA catabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis