InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: XRN1

Summary

InnateDB Gene

IDBG-59457.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XRN1

Gene Name

5'-3' exoribonuclease 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000114127

Encoded Proteins

IDBP-59459

5'-3' exoribonuclease 1

IDBP-244529

5'-3' exoribonuclease 1

IDBP-484103

5'-3' exoribonuclease 1

IDBP-483939

5'-3' exoribonuclease 1

IDBP-478203

5'-3' exoribonuclease 1

IDBP-474100

5'-3' exoribonuclease 1

IDBP-484992

5'-3' exoribonuclease 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:142306607-142448062

Strand

Reverse strand

Band

q23

Transcripts

ENST00000264951	ENSP00000264951
ENST00000392981	ENSP00000376707
ENST00000498077	ENSP00000419683
ENST00000489241	ENSP00000419219
ENST00000468894
ENST00000467077
ENST00000472625
ENST00000472697
ENST00000465507
ENST00000463916	ENSP00000418404
ENST00000486211	ENSP00000420786
ENST00000477237	ENSP00000420634
ENST00000470537
ENST00000465074

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.

Experimentally validated
Total	74 [view]
Protein-Protein	74 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0008409	5'-3' exonuclease activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000956	nuclear-transcribed mRNA catabolic process
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0016075	rRNA catabolic process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0071028	nuclear mRNA surveillance
GO:0071044	histone mRNA catabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005622	intracellular
GO:0005829	cytosol
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032410

View Gene Order

ENSBTAG00000011524

Not yet available

Pathways

NETPATH

REACTOME

REACT_24915

Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway

REACT_25064

Tristetraprolin (TTP) destabilizes mRNA pathway

REACT_20518

mRNA decay by 5' to 3' exoribonuclease pathway

REACT_20639

Deadenylation-dependent mRNA decay pathway

REACT_24994

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_71

Gene Expression pathway

KEGG

hsa03018

RNA degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.435103 Hs.629790

RefSeq

NM_001282857 NM_001282859 NM_019001 XM_005247544 XM_006713671 XM_006713673

HUGO

OMIM

CCDS

CCDS3123 CCDS63801 CCDS75028

HPRD

10470

IMGT

EMBL

GenPept

RNA Seq Atlas