Version 5.4
Homo sapiens Protein: SYCP3
Summary
InnateDB Protein IDBP-244663.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYCP3
Protein Name synaptonemal complex protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376658
InnateDB Gene IDBG-53386 (SYCP3)
Protein Structure
UniProt Annotation
Function Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed. {ECO:0000250}.
Disease Associations Spermatogenic failure 4 (SPGF4) [MIM:270960]: An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. {ECO:0000269PubMed:14643120}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Testis-specific. {ECO:0000269PubMed:12213195, ECO:0000269PubMed:14643120}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0007141 male meiosis I
GO:0035093 spermatogenesis, exchange of chromosomal proteins
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
Protein Structure and Domains
PDB ID
InterPro IPR006888 Cor1/Xlr/Xmr family
PFAM PF04803
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IZU3
PhosphoSite PhosphoSite-Q8IZU3
TrEMBL A0A024RBF8
UniProt Splice Variant
Entrez Gene 50511
UniGene Hs.506504
RefSeq NP_710161
HUGO HGNC:18130
OMIM 604759
CCDS CCDS9087
HPRD 07265
IMGT
EMBL AF492003 AF517774 BC062662 CH471054
GenPept AAH62662 AAN06611 AAP47204 EAW97678 EAW97680 EAW97681

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca