Version 5.4
Homo sapiens Gene: SYCP3
Summary
InnateDB Gene IDBG-53386.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYCP3
Gene Name synaptonemal complex protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139351
Encoded Proteins
IDBP-53388
synaptonemal complex protein 3
IDBP-244663
synaptonemal complex protein 3
IDBP-244665
synaptonemal complex protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:101728648-101739472
Strand Reverse strand
Band q23.2
Transcripts
ENST00000266743 ENSP00000266743
ENST00000392927 ENSP00000376658
ENST00000392924 ENSP00000376655
ENST00000478139
ENST00000478238
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0007141 male meiosis I
GO:0035093 spermatogenesis, exchange of chromosomal proteins
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020059
View Gene Order
ENSBTAG00000002492
Not yet available
Pathways
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8IZU3
TrEMBL A0A024RBF8
UniProt Splice Variant
Entrez Gene 50511
UniGene Hs.506504
RefSeq NM_001177948 NM_001177949 NM_153694 XM_005268923
HUGO HGNC:18130
OMIM 604759
CCDS CCDS9087
HPRD 07265
IMGT
EMBL AF492003 AF517774 BC062662 CH471054
GenPept AAH62662 AAN06611 AAP47204 EAW97678 EAW97680 EAW97681
RNA Seq Atlas 50511

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca