InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HLTF

Summary

InnateDB Protein

IDBP-244681.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLTF

Protein Name

helicase-like transcription factor

Synonyms

HIP116; HIP116A; HLTF1; RNF80; SMARCA3; SNF2L3; ZBU1;

Species

Homo sapiens

Ensembl Protein

ENSP00000376644

InnateDB Gene

IDBG-60482 (HLTF)

Protein Structure

UniProt Annotation

Function

Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. {ECO:0000250, ECO:0000269PubMed:10391891, ECO:0000269PubMed:18316726, ECO:0000269PubMed:18719106, ECO:0000269PubMed:7876228, ECO:0000269PubMed:8672239, ECO:0000269PubMed:9126292}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269PubMed:8672239}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Nuclear localization is stimulated by progesterone. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269PubMed:8672239, ECO:0000269PubMed:9126292}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	44 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016567	protein ubiquitination
GO:0016568	chromatin modification

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR001841 Zinc finger, RING-type
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014905 HIRAN domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF13639
PF14634
PF08797

PRINTS

PIRSF

SMART

SM00490
SM00184
SM00487
SM00910

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14527