InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HLTF

Summary

InnateDB Gene

IDBG-60482.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLTF

Gene Name

helicase-like transcription factor

Synonyms

HIP116; HIP116A; HLTF1; RNF80; SMARCA3; SNF2L3; ZBU1

Species

Homo sapiens

Ensembl Gene

ENSG00000071794

Encoded Proteins

IDBP-60484

helicase-like transcription factor

IDBP-244681

helicase-like transcription factor

IDBP-480942

helicase-like transcription factor

IDBP-481067

helicase-like transcription factor

IDBP-485307

helicase-like transcription factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:149030127-149086554

Strand

Reverse strand

Band

q24

Transcripts

ENST00000310053	ENSP00000308944
ENST00000392912	ENSP00000376644
ENST00000465259	ENSP00000420745
ENST00000494055	ENSP00000420429
ENST00000467858	ENSP00000420106
ENST00000472830
ENST00000497427
ENST00000493881
ENST00000481663

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	44 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016874	ligase activity
GO:0016887	ATPase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008152	metabolic process
GO:0016567	protein ubiquitination
GO:0016568	chromatin modification

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016020	membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002428

View Gene Order

ENSBTAG00000019704

Not yet available

Pathways

NETPATH

NetPath_56

Prolactin pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.3068 Hs.594973 Hs.708498

RefSeq

NM_003071 NM_139048 XM_005247724

HUGO

OMIM

CCDS

CCDS33875

HPRD

04461

IMGT

EMBL

GenPept

RNA Seq Atlas